TGF-beta/Smad
EZH2
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Product name : Ribociclib (LEE011, LEE-011)
Product No. : 201661714257
Price : 100mg, $475, 500mg/$975
CAS :
Bulk inquiry :
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| Details: |
LEE011 (CAS: 1211441-98-3) is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
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