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Products > Metabolic enzyme/Protease > Isocitrate Dehydrogenases > Ivosidenib (AG-120, AG120, AG 120)
Ivosidenib (AG-120, AG120, AG 120)
Product name : Ivosidenib (AG-120, AG120, AG 120)
Product No. : cs-1644
Price : 100mg, $475, 500mg/$1275
CAS : 
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  Details:
 AG-120 (CAS: 1448346-63-1) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells. 

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