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Products > JAK/STAT Signaling > JAK > XL-019 (XL019, XL 019)
XL-019 (XL019, XL 019)
Product name : XL-019 (XL019, XL 019)
Product No. : cs-800
Price : 100mg, $475, 500mg/$1275
CAS : 
Bulk inquiry : 
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  Details:
XL019 (CAS: 945755-56-6) is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1. XL019 inhibits the activation of JAK2 as well as the mutated form JAK2V617F, which may result in the inhibition of the JAK-STAT signaling pathway and may induce apoptosis. The JAK2 mutated form JAK2V617F has a valine-to-phenylalanine modification at position 617 and plays a key role in tumor cell proliferation and survival.

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