Calpain Inhibitor III (CAS: 88191-84-8) is a cell permeable, selective inhibitor of μ-calpain (calpain-1) and m-calpain (calpain-2). Calpain Inhibitor III crosses the blood-brain barrier to inhibit brain cysteine protease activity and has been reported to have neuroprotective effects in numerous rodent neurotrauma models, including spinal cord injury, cortical impact trauma, neonatal hypoxia-ischemia, and focal cerebral ischemia. Additionally, Calpain Inhibitor III has been shown to attenuate depression in myocardial contractile performance that occurs during reperfusion following cardiac ischemia.
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TGF-beta/Smad
Nampt
