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Products > Protein Tyrosine Kinase/RTK > ALK > CEP-37440 (CEP37440, CEP 37440)
CEP-37440 (CEP37440, CEP 37440)
Product name : CEP-37440 (CEP37440, CEP 37440)
Product No. : cs-1603
Price : 100mg, $675, 500mg/$1875
CAS : 
Bulk inquiry : 
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  Details:
 CEP-37440 (CAS: 1391712-60-9) is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).  CEP-37440 selectively binds to and inhibits ALK kinase and FAK kinase. The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; its dysregulation and gene rearrangements are associated with a variety of tumors.

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